A SKOS Core approach to implementing an M2M

The proliferation of distributed digital libraries and repositories has increased the need for improved interoperability between terminologies in order to facilitate user access to the discrete heterogeneous digital objects held therein. The emergence of the Simple Knowledge Organization System (SKOS) Core is a useful development in this context. In this paper we describe a SKOS Core approach to implementing a web services (i.e. M2M) terminology server employing terminology mapping and using SKOS Core to wrap terminology responses. Aspects advantageous to this approach are explored, as are issues and areas for future research

SPEIR: Scottish Portals for Education, Information and Research. Final Project Report: Elements and Future Development Requirements of a Common Information Environment for Scotland

The SPEIR (Scottish Portals for Education, Information and Research) project was funded by the Scottish Library and Information Council (SLIC). It ran from February 2003 to September 2004, slightly longer than the 18 months originally scheduled and was managed by the Centre for Digital Library Research (CDLR). With SLIC's agreement, community stakeholders were represented in the project by the Confederation of Scottish Mini-Cooperatives (CoSMiC), an organisation whose members include SLIC, the National Library of Scotland (NLS), the Scottish Further Education Unit (SFEU), the Scottish Confederation of University and Research Libraries (SCURL), regional cooperatives such as the Ayrshire Libraries Forum (ALF)1, and representatives from the Museums and Archives communities in Scotland. Aims; A Common Information Environment For Scotland The aims of the project were to: o Conduct basic research into the distributed information infrastructure requirements of the Scottish Cultural Portal pilot and the public library CAIRNS integration proposal; o Develop associated pilot facilities by enhancing existing facilities or developing new ones; o Ensure that both infrastructure proposals and pilot facilities were sufficiently generic to be utilised in support of other portals developed by the Scottish information community; o Ensure the interoperability of infrastructural elements beyond Scotland through adherence to established or developing national and international standards. Since the Scottish information landscape is taken by CoSMiC members to encompass relevant activities in Archives, Libraries, Museums, and related domains, the project was, in essence, concerned with identifying, researching, and developing the elements of an internationally interoperable common information environment for Scotland, and of determining the best path for future progress

Relation of Trauma, Disease, and Law - Panel Discussion

A symposium on Relation of Trama, Disease, and Law. The symposium took place under the auspices of the Amerian Board of Legal Medicine Inc., in conjucntion with the sesquicentennial meeting of the Medical Society of the State of New York

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

The immunosurveillance of transformed cells by the immune system remains one of the most controversial and poorly understood areas of immunity. Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). Both IFN-γ and pfp were critical for suppression of lymphomagenesis, however the level of protection afforded by IFN-γ was strain specific. Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. Single loss of IL-12, IL-18, or TNF was not sufficient for spontaneous tumor development. A significant incidence of late onset adenocarcinoma observed in both IFN-γ– and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance

Relation of Trauma, Disease, and Law - Panel Discussion

A symposium on Relation of Trama, Disease, and Law. The symposium took place under the auspices of the Amerian Board of Legal Medicine Inc., in conjucntion with the sesquicentennial meeting of the Medical Society of the State of New York

Disagreements Within the US Food and Drug Administration Regarding Approval of Novel Therapeutic Agents, 2011-2015

Thirty days after a novel therapeutic agent, a new molecular entity, or original biologic is approved, the US Food and Drug Administration (FDA) must publicly disclose its approval package, including scientific reviews completed by FDA disciplines (eg, pharmacology, statistical, and medical reviewers) and any available assessments by agency leadership.1 Although reports of internal disagreement have surfaced,2 it is unclear how often such disagreements occur. Disagreements document differing points of view or engaged discussion and may, thus, capture important scientific debates or signal challenging decisions within the agency. We sought to determine the frequency of disagreements within the FDA regarding approval of novel therapeutic agents

A Second Large Subglacial Impact Crater in Northwest Greenland?

Following the discovery of the Hiawatha impact crater beneath the northwest margin of the Greenland Ice Sheet, we explored satellite and aerogeophysical data in search of additional such craters. Here we report the discovery of a possible second subglacial impact crater that is 36.5 km wide and 183 km southeast of the Hiawatha impact crater. Although buried by 2 km of ice, the structure's rim induces a conspicuously circular surface expression, it possesses a central uplift and it causes a negative gravity anomaly. The existence of two closely-spaced and similarlysized complex craters raises the possibility that they formed during related impact events. However, the second structure's morphology is shallower, its overlying ice is conformal and older, and such an event can be explained by chance. We conclude that the identified structure is very likely an impact crater, but it is unlikely to be a twin of the Hiawatha impact crater

The abandoned ice sheet base at Camp Century, Greenland, in a warming climate

In 1959 the U.S. Army Corps of Engineers built Camp Century beneath the surface of the northwestern Greenland Ice Sheet. There they studied the feasibility of deploying ballistic missiles within the ice sheet. The base and its wastes were abandoned with minimal decommissioning in 1967, under the assumption they would be preserved for eternity by perpetually accumulating snowfall. Here we show that a transition in ice sheet surface mass balance at Camp Century from net accumulation to net ablation is plausible within the next 75 years, under a business-as-usual anthropogenic emissions scenario (Representative Concentration Pathway 8.5). Net ablation would guarantee the eventual remobilization of physical, chemical, biological, and radiological wastes abandoned at the site. While Camp Century and four other contemporaneous ice sheet bases were legally established under a Danish-U.S. treaty, the potential remobilization of their abandoned wastes, previously regarded as sequestered, represents an entirely new pathway of political dispute resulting from climate change

Modeling Englacial Radar Attenuation at Siple Dome, West Antarctica, Using Ice Chemistry and Temperature Data

The radar reflectivity of an ice-sheet bed is a primary measurement for discriminating between thawed and frozen beds. Uncertainty in englacial radar attenuation and its spatial variation introduces corresponding uncertainty in estimates of basal reflectivity. Radar attenuation is proportional to ice conductivity, which depends on the concentrations of acid and sea-salt chloride and the temperature of the ice. We synthesize published conductivity measurements to specify an ice-conductivity model and find that some of the dielectric properties of ice at radar frequencies are not yet well constrained. Using depth profiles of ice-core chemistry and borehole temperature and an average of the experimental values for the dielectric properties, we calculate an attenuation rate profile for Siple Dome, West Antarctica. The depth-averaged modeled attenuation rate at Siple Dome (20.0 +/- 5.7 dB km(-1)) is somewhat lower than the value derived from radar profiles (25.3 +/- 1.1 dB km(-1)). Pending more experimental data on the dielectric properties of ice, we can match the modeled and radar-derived attenuation rates by an adjustment to the value for the pure ice conductivity that is within the range of reported values. Alternatively, using the pure ice dielectric properties derived from the most extensive single data set, the modeled depth-averaged attenuation rate is 24.0 +/- 2.2 dB km(-1). This work shows how to calculate englacial radar attenuation using ice chemistry and temperature data and establishes a basis for mapping spatial variations in radar attenuation across an ice sheet